Combining biomarkers and TIMI score for prediction of left ventricular systolic dysfunction among patients with STEMI

Abstract

The aim of the study was to evaluate possibility combining biomarkers and Thrombolisis In Myocardial Infarction score for prediction of the left ventricular systolic dysfunction among patients with ST-segment elevation myocardial infarction. Methods: the results of the study are based on data obtained from a comprehensive survey of 280 patients with ST-segment elevation myocardial infarction, the average age was 60,0 [53,0 ; 64,0] years. All persons were comparable in age, social status, and gender. Results: We found that the basic model was determined by Thrombolisis In Myocardial Infarction score, Se 24,00 % and 86,96 % at Area Under the ROC curve = 0,58 (95% confidence interval 0,515-0,634) with cut off 4 points for the left ventricular systolic dysfunction. To determination of the baseline model with simultaneous three biomarkers (troponin І, metalloproteinase-9, interleukin-6) allowed us to improve the prognosis of left ventricular systolic dysfunction in patients with ST-segment elevation myocardial infarction.