Prognostic Value of Cytokines for Ischemic Heart Disease in Patients with Hypertension Stage II

Abstract

Aim of the study is to determine the predictive value with respect to the development of coronary heart disease (CHD) of inflammatory activity, in patients with hypertension (HT) stage II. Methods: We examined 180 patients (men and women) with documented HT stage II. All surveyed people were divided into two groups: the first group consisted of 130 primary HT patients stage II without CHD, the average age of 56.5±0.5 years; a second comparison group – 50 patients with CHD combined with HT II stage, average age of 58.1±0.8 years. Results: The results of the ROC-analysis showed significantly higher (AUC = 0.87) (95% CI AUC 0,812-0,915) predictive value ratio of IL-1β / IL-10 in the development of coronary artery disease in hypertensive patients, with an optimal distribution of the threshold of > 1.7 sensitivity was 64.0 % and specificity - 94.6 %. The high sensitivity (90.0%), to the development of coronary artery disease in hypertensive patients was significantly (AUC = 0,87) hs-CRP found at the point of separation of> 4.7 mg / L specificity was 72.3%.