Стан ліпідного обміну у пацієнтів з синдромом обструктивного апное сну та нормальною вагою тіла

Abstract

Мета. Дослідити стан ліпідного обміну у хворих на СОАС з нормальною вагою тіла. Introduction. The urgency of the problem of breathing disorder during sleep, especially sleep apnea syndrome obstructive, gained over the last decade. It is proved that the syndrome of obstructive sleep apnea increases cardiovascular morbidity and mortality, impact on glucose and lipid metabolisms, induce development of arrhythmias and worsens of endocrine diseases. Object. Investigate the state of lipid metabolism in patients with obstructive sleep apnea syndrome with normal body weight. Materials and Methods. the study involved 56 patients with OSA and 20 control individuals. All participants in addition to general clinical research performed cardiorespiratory monitoring. Total cholesterol was determined, lipoprotein low (LDL) and high density (HDL), triglycerides (TG), apolipoprotein A1 and B1. Results and conclusions. The study established that 41% of patients with OSA were found increasing total cholesterol above 6 mg / dL. Values ranged within 3.5 - 9.6 mmol / l. Significant changes in lipid metabolism found in patients with OSA and normal body weight index for the total cholesterol group and for HDL, LDL, TG and Apo-A1 for patients with severe respiratory disorders in OSA.